diff --git a/compiler/rustc_codegen_llvm/src/debuginfo/metadata/enums/mod.rs b/compiler/rustc_codegen_llvm/src/debuginfo/metadata/enums/mod.rs
index 556158c286a84..f7fe0eb8cb3b8 100644
--- a/compiler/rustc_codegen_llvm/src/debuginfo/metadata/enums/mod.rs
+++ b/compiler/rustc_codegen_llvm/src/debuginfo/metadata/enums/mod.rs
@@ -21,8 +21,8 @@ use crate::debuginfo::metadata::{
     file_metadata_from_def_id, type_di_node, unknown_file_metadata,
 };
 use crate::debuginfo::utils::{DIB, create_DIArray, get_namespace_for_item};
-use crate::llvm;
 use crate::llvm::debuginfo::{DIFlags, DIType};
+use crate::llvm::{self, ToLlvmBool};
 
 mod cpp_like;
 mod native;
@@ -111,16 +111,23 @@ fn build_enumeration_type_di_node<'ll, 'tcx>(
     let (size, align) = cx.size_and_align_of(base_type);
 
     let enumerator_di_nodes: SmallVec<Option<&'ll DIType>> = enumerators
-        .map(|(name, value)| unsafe {
-            let value = [value as u64, (value >> 64) as u64];
-            Some(llvm::LLVMRustDIBuilderCreateEnumerator(
-                DIB(cx),
-                name.as_c_char_ptr(),
-                name.len(),
-                value.as_ptr(),
-                size.bits() as libc::c_uint,
-                is_unsigned,
-            ))
+        .map(|(name, value)| {
+            let value_words = [value as u64, (value >> 64) as u64];
+            let size_in_bits = size.bits();
+            // LLVM computes `NumWords = (SizeInBits + 63) / 64`.
+            assert!((size_in_bits + 63) / 64 <= value_words.len() as u64);
+
+            let enumerator = unsafe {
+                llvm::LLVMDIBuilderCreateEnumeratorOfArbitraryPrecision(
+                    DIB(cx),
+                    name.as_ptr(),
+                    name.len(),
+                    size_in_bits,
+                    value_words.as_ptr(),
+                    is_unsigned.to_llvm_bool(),
+                )
+            };
+            Some(enumerator)
         })
         .collect();
 
diff --git a/compiler/rustc_codegen_llvm/src/llvm/ffi.rs b/compiler/rustc_codegen_llvm/src/llvm/ffi.rs
index 2728152b5d209..eb9b2ab121296 100644
--- a/compiler/rustc_codegen_llvm/src/llvm/ffi.rs
+++ b/compiler/rustc_codegen_llvm/src/llvm/ffi.rs
@@ -22,9 +22,8 @@ use libc::{c_char, c_int, c_uchar, c_uint, c_ulonglong, c_void, size_t};
 
 use super::RustString;
 use super::debuginfo::{
-    DIArray, DIBuilder, DIDerivedType, DIDescriptor, DIEnumerator, DIFile, DIFlags, DILocation,
-    DISPFlags, DIScope, DISubprogram, DITemplateTypeParameter, DIType, DebugEmissionKind,
-    DebugNameTableKind,
+    DIArray, DIBuilder, DIDerivedType, DIDescriptor, DIFile, DIFlags, DILocation, DISPFlags,
+    DIScope, DISubprogram, DITemplateTypeParameter, DIType, DebugEmissionKind, DebugNameTableKind,
 };
 use crate::llvm::MetadataKindId;
 use crate::{TryFromU32, llvm};
@@ -752,7 +751,6 @@ pub(crate) mod debuginfo {
     pub(crate) type DICompositeType = DIDerivedType;
     pub(crate) type DIVariable = DIDescriptor;
     pub(crate) type DIArray = DIDescriptor;
-    pub(crate) type DIEnumerator = DIDescriptor;
     pub(crate) type DITemplateTypeParameter = DIDescriptor;
 
     bitflags! {
@@ -1794,6 +1792,15 @@ unsafe extern "C" {
         Flags: DIFlags, // (default is `DIFlags::DIFlagZero`)
     ) -> &'ll Metadata;
 
+    pub(crate) fn LLVMDIBuilderCreateEnumeratorOfArbitraryPrecision<'ll>(
+        Builder: &DIBuilder<'ll>,
+        Name: *const c_uchar, // See "PTR_LEN_STR".
+        NameLen: size_t,
+        SizeInBits: u64,
+        Words: *const u64, // LLVM computes `NumWords = (SizeInBits + 63) / 64`.
+        IsUnsigned: llvm::Bool,
+    ) -> &'ll Metadata;
+
     pub(crate) fn LLVMDIBuilderCreateUnionType<'ll>(
         Builder: &DIBuilder<'ll>,
         Scope: Option<&'ll Metadata>,
@@ -1989,6 +1996,7 @@ unsafe extern "C" {
     pub(crate) fn LLVMRustDisableSystemDialogsOnCrash();
 
     // Operations on all values
+    /// FIXME: After dropping LLVM 21, migrate to LLVM-C's `LLVMGlobalAddMetadata`.
     pub(crate) fn LLVMRustGlobalAddMetadata<'a>(
         Val: &'a Value,
         KindID: MetadataKindId,
@@ -2058,6 +2066,7 @@ unsafe extern "C" {
     ) -> &Attribute;
 
     // Operations on functions
+    /// FIXME: After dropping LLVM 21, migrate to LLVM-C's `LLVMGetOrInsertFunction`.
     pub(crate) fn LLVMRustGetOrInsertFunction<'a>(
         M: &'a Module,
         Name: *const c_char,
@@ -2208,6 +2217,9 @@ unsafe extern "C" {
         ValueLen: size_t,
     );
 
+    /// We can't use LLVM-C's `LLVMDIBuilderCreateCompileUnit` because it hardcodes
+    /// `DICompileUnit::DebugNameTableKind::Default`, but we want to be able to
+    /// pass other values.
     pub(crate) fn LLVMRustDIBuilderCreateCompileUnit<'a>(
         Builder: &DIBuilder<'a>,
         Lang: c_uint,
@@ -2225,6 +2237,8 @@ unsafe extern "C" {
         DebugNameTableKind: DebugNameTableKind,
     ) -> &'a DIDescriptor;
 
+    /// We can't use LLVM-C's `LLVMDIBuilderCreateFileWithChecksum` because it
+    /// _requires_ a checksum, but we sometimes don't provide one.
     pub(crate) fn LLVMRustDIBuilderCreateFile<'a>(
         Builder: &DIBuilder<'a>,
         Filename: *const c_char,
@@ -2238,6 +2252,8 @@ unsafe extern "C" {
         SourceLen: size_t,
     ) -> &'a DIFile;
 
+    /// We can't use LLVM-C's `LLVMDIBuilderCreateFunction` because it only
+    /// supports a subset of `DISubprogram::DISPFlags`.
     pub(crate) fn LLVMRustDIBuilderCreateFunction<'a>(
         Builder: &DIBuilder<'a>,
         Scope: &'a DIDescriptor,
@@ -2256,6 +2272,7 @@ unsafe extern "C" {
         Decl: Option<&'a DIDescriptor>,
     ) -> &'a DISubprogram;
 
+    /// As of LLVM 22 there is no corresponding LLVM-C function.
     pub(crate) fn LLVMRustDIBuilderCreateMethod<'a>(
         Builder: &DIBuilder<'a>,
         Scope: &'a DIDescriptor,
@@ -2271,6 +2288,7 @@ unsafe extern "C" {
         TParam: &'a DIArray,
     ) -> &'a DISubprogram;
 
+    /// As of LLVM 22 there is no corresponding LLVM-C function.
     pub(crate) fn LLVMRustDIBuilderCreateVariantMemberType<'a>(
         Builder: &DIBuilder<'a>,
         Scope: &'a DIScope,
@@ -2286,15 +2304,7 @@ unsafe extern "C" {
         Ty: &'a DIType,
     ) -> &'a DIType;
 
-    pub(crate) fn LLVMRustDIBuilderCreateEnumerator<'a>(
-        Builder: &DIBuilder<'a>,
-        Name: *const c_char,
-        NameLen: size_t,
-        Value: *const u64,
-        SizeInBits: c_uint,
-        IsUnsigned: bool,
-    ) -> &'a DIEnumerator;
-
+    /// As of LLVM 22 there is no corresponding LLVM-C function.
     pub(crate) fn LLVMRustDIBuilderCreateEnumerationType<'a>(
         Builder: &DIBuilder<'a>,
         Scope: &'a DIScope,
@@ -2309,6 +2319,7 @@ unsafe extern "C" {
         IsScoped: bool,
     ) -> &'a DIType;
 
+    /// As of LLVM 22 there is no corresponding LLVM-C function.
     pub(crate) fn LLVMRustDIBuilderCreateVariantPart<'a>(
         Builder: &DIBuilder<'a>,
         Scope: &'a DIScope,
@@ -2325,6 +2336,7 @@ unsafe extern "C" {
         UniqueIdLen: size_t,
     ) -> &'a DIDerivedType;
 
+    /// As of LLVM 22 there is no corresponding LLVM-C function.
     pub(crate) fn LLVMRustDIBuilderCreateTemplateTypeParameter<'a>(
         Builder: &DIBuilder<'a>,
         Scope: Option<&'a DIScope>,
@@ -2333,6 +2345,8 @@ unsafe extern "C" {
         Ty: &'a DIType,
     ) -> &'a DITemplateTypeParameter;
 
+    /// We can't use LLVM-C's `LLVMReplaceArrays` because it doesn't take a
+    /// `Params` argument.
     pub(crate) fn LLVMRustDICompositeTypeReplaceArrays<'a>(
         Builder: &DIBuilder<'a>,
         CompositeType: &'a DIType,
@@ -2340,6 +2354,8 @@ unsafe extern "C" {
         Params: Option<&'a DIArray>,
     );
 
+    /// We can't use LLVM-C's `LLVMDIBuilderGetOrCreateSubrange` because it doesn't
+    /// call the overload that takes a `Metadata` upper bound.
     pub(crate) fn LLVMRustDIGetOrCreateSubrange<'a>(
         Builder: &DIBuilder<'a>,
         CountNode: Option<&'a Metadata>,
@@ -2348,6 +2364,8 @@ unsafe extern "C" {
         Stride: Option<&'a Metadata>,
     ) -> &'a Metadata;
 
+    /// We can't use LLVM-C's `LLVMDIBuilderCreateVectorType` because it doesn't
+    /// take a `BitStride` argument.
     pub(crate) fn LLVMRustDICreateVectorType<'a>(
         Builder: &DIBuilder<'a>,
         Size: u64,
@@ -2357,6 +2375,7 @@ unsafe extern "C" {
         BitStride: Option<&'a Metadata>,
     ) -> &'a Metadata;
 
+    /// As of LLVM 22 there is no corresponding LLVM-C function.
     pub(crate) fn LLVMRustDILocationCloneWithBaseDiscriminator<'a>(
         Location: &'a DILocation,
         BD: c_uint,
diff --git a/compiler/rustc_llvm/llvm-wrapper/RustWrapper.cpp b/compiler/rustc_llvm/llvm-wrapper/RustWrapper.cpp
index 63e3119ee96f7..28037d28fa44a 100644
--- a/compiler/rustc_llvm/llvm-wrapper/RustWrapper.cpp
+++ b/compiler/rustc_llvm/llvm-wrapper/RustWrapper.cpp
@@ -1198,15 +1198,6 @@ extern "C" LLVMMetadataRef LLVMRustDIBuilderCreateVariantMemberType(
       fromRust(Flags), unwrapDI<DIType>(Ty)));
 }
 
-extern "C" LLVMMetadataRef
-LLVMRustDIBuilderCreateEnumerator(LLVMDIBuilderRef Builder, const char *Name,
-                                  size_t NameLen, const uint64_t Value[2],
-                                  unsigned SizeInBits, bool IsUnsigned) {
-  return wrap(unwrap(Builder)->createEnumerator(
-      StringRef(Name, NameLen),
-      APSInt(APInt(SizeInBits, ArrayRef<uint64_t>(Value, 2)), IsUnsigned)));
-}
-
 extern "C" LLVMMetadataRef LLVMRustDIBuilderCreateEnumerationType(
     LLVMDIBuilderRef Builder, LLVMMetadataRef Scope, const char *Name,
     size_t NameLen, LLVMMetadataRef File, unsigned LineNumber,