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It depends on what you want to achieve.
For investigating a particular component or behavior, REA supports native binary analysis, including pseudocode, assembly, strings, and references through tools such as Ghidra. That doesn’t establish that it can reconstruct the entire Office suite automatically.
If your goal is reading or writing .docx, .xlsx, or .pptx files, you can start with the documented Office Open XML formats. Microsoft provides an Open XML SDK for manipulating those documents.
If you mainly want a free office suite, LibreOffice already provides a word processor, spreadsheet application, and presentation editor.
Are you trying to understand a specific Office feature, work with its document formats, or build an alternative application? That would help narrow down a practical approach.
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Can Microsoft Office be reverse-engineered?
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