diff --git a/setup.py b/setup.py
index d4edfff484..7202e9c7bd 100644
--- a/setup.py
+++ b/setup.py
@@ -49,6 +49,10 @@ def get_version() -> str:
 
 extras["mcp"] = ["mcp>=1.8.0"]
 
+extras["jobs"] = [
+    "cloudpickle",
+]
+
 extras["testing"] = (
     extras["oauth"]
     + [
diff --git a/src/huggingface_hub/__init__.py b/src/huggingface_hub/__init__.py
index aab27232ba..92a0e8b347 100644
--- a/src/huggingface_hub/__init__.py
+++ b/src/huggingface_hub/__init__.py
@@ -177,6 +177,7 @@
         "add_collection_item",
         "add_space_secret",
         "add_space_variable",
+        "as_job",
         "auth_check",
         "cancel_access_request",
         "cancel_job",
@@ -820,6 +821,7 @@
     "add_collection_item",
     "add_space_secret",
     "add_space_variable",
+    "as_job",
     "attach_huggingface_oauth",
     "auth_check",
     "auth_list",
@@ -1203,6 +1205,7 @@ def __dir__():
         add_collection_item,  # noqa: F401
         add_space_secret,  # noqa: F401
         add_space_variable,  # noqa: F401
+        as_job,  # noqa: F401
         auth_check,  # noqa: F401
         cancel_access_request,  # noqa: F401
         cancel_job,  # noqa: F401
diff --git a/src/huggingface_hub/hf_api.py b/src/huggingface_hub/hf_api.py
index 89e442bc1e..72e3a8cec7 100644
--- a/src/huggingface_hub/hf_api.py
+++ b/src/huggingface_hub/hf_api.py
@@ -19,6 +19,8 @@
 import json
 import re
 import struct
+import sys
+import tempfile
 import time
 import warnings
 from collections import defaultdict
@@ -37,6 +39,7 @@
     Iterator,
     Literal,
     Optional,
+    ParamSpec,
     TypeVar,
     Union,
     overload,
@@ -114,6 +117,7 @@
     from .inference._providers import PROVIDER_T
     from .utils._verification import FolderVerification
 
+P = ParamSpec("P")  # Parameters
 R = TypeVar("R")  # Return type
 CollectionItemType_T = Literal["model", "dataset", "space", "paper", "collection"]
 
@@ -10417,6 +10421,141 @@ def run_uv_job(
             token=token,
         )
 
+    @experimental
+    def as_job(
+        self,
+        *,
+        dependencies: Optional[list[str]] = None,
+        python: Optional[str] = None,
+        env: Optional[dict[str, Any]] = None,
+        secrets: Optional[dict[str, Any]] = None,
+        flavor: Optional[SpaceHardware] = None,
+        timeout: Optional[Union[int, float, str]] = None,
+        namespace: Optional[str] = None,
+        token: Union[bool, str, None] = None,
+    ) -> Callable[[Callable[P, R]], Callable[P, R]]:
+        """
+        Decorator to easily run functions as remote Jobs on Hugging Face.
+
+        Args:
+            dependencies (`list[str]`, *optional*)
+                Dependencies to use to run the UV script.
+
+            python (`str`, *optional*)
+                Use a specific Python version. Default is 3.12.
+
+            env (`dict[str, Any]`, *optional*):
+                Defines the environment variables for the Job.
+
+            secrets (`dict[str, Any]`, *optional*):
+                Defines the secret environment variables for the Job.
+
+            flavor (`str`, *optional*):
+                Flavor for the hardware, as in Hugging Face Spaces. See [`SpaceHardware`] for possible values.
+                Defaults to `"cpu-basic"`.
+
+            timeout (`Union[int, float, str]`, *optional*):
+                Max duration for the Job: int/float with s (seconds, default), m (minutes), h (hours) or d (days).
+                Example: `300` or `"5m"` for 5 minutes.
+
+            namespace (`str`, *optional*):
+                The namespace where the Job will be created. Defaults to the current user's namespace.
+
+            token `(Union[bool, str, None]`, *optional*):
+                A valid user access token. If not provided, the locally saved token will be used, which is the
+                recommended authentication method. Set to `False` to disable authentication.
+                Refer to: https://huggingface.co/docs/huggingface_hub/quick-start#authentication.
+        """
+        try:
+            import cloudpickle
+        except ImportError as e:
+            raise ImportError(
+                "cloudpickle is required to use the 'as_job' decorator. Please install it with `pip install huggingface_hub[jobs]` or `pip install cloudpickle`."
+            ) from e
+
+        # NOTE: for cloudpickle to work we must have the exact same python version as the client
+        # We also need uv to launch the script. This is why docker image is currently not customizable.
+        #
+        # NOTE: here we select Python major.minor version, but cloudpickle might still fail if
+        # the user has a different micro version or different platform (e.g., Windows vs Linux).
+        #
+        # TODO: make this more robust (e.g. by sending a Dockerfile directly in the payload?)
+        image = f"ghcr.io/astral-sh/uv:python{sys.version_info.major}.{sys.version_info.minor}-bookworm"
+        dependencies = dependencies or []
+        dependencies.append(f"cloudpickle=={cloudpickle.__version__}")
+
+        def decorator(func: Callable[P, R]) -> Callable[P, R]:
+            def wrapper(*args: P.args, **kwargs: P.kwargs) -> R:
+                script_bytes = cloudpickle.dumps(func)
+                script_b64 = base64.b64encode(script_bytes).decode("utf-8")
+
+                args_bytes = cloudpickle.dumps((args, kwargs))
+                args_b64 = base64.b64encode(args_bytes).decode("utf-8")
+
+                script = f"""
+import base64
+import cloudpickle
+
+script_b64 = "{script_b64}"
+args_b64 = "{args_b64}"
+
+script_bytes = base64.b64decode(script_b64)
+func = cloudpickle.loads(script_bytes)
+
+args_bytes = base64.b64decode(args_b64)
+args, kwargs = cloudpickle.loads(args_bytes)
+
+result = func(*args, **kwargs)
+
+results_b64 = base64.b64encode(cloudpickle.dumps(result)).decode("utf-8")
+
+print("result: ", results_b64)
+"""
+
+                with tempfile.NamedTemporaryFile("w+", suffix=".py") as tmp_script_file:
+                    tmp_script_file.write(script)
+                    tmp_script_file.flush()
+
+                    uv_command, uv_env, uv_secrets = self._create_uv_command_env_and_secrets(
+                        script=tmp_script_file.name,
+                        script_args=[],
+                        dependencies=dependencies,
+                        python=python,
+                        env=env,
+                        secrets=secrets,
+                        namespace=namespace,
+                        token=token,
+                    )
+
+                    job = self.run_job(
+                        image=image,
+                        command=uv_command,
+                        env=uv_env,
+                        secrets=uv_secrets,
+                        flavor=flavor,
+                        timeout=timeout,
+                        namespace=namespace,
+                        token=token,
+                    )
+
+                print(f"Job {job.id} is running remotely. Fetching logs:")
+                print(job.url)
+                print("-----")
+                for log in self.fetch_job_logs(job_id=job.id):
+                    if log.startswith("result: "):
+                        result_b64 = log[len("result: ") :]
+                        result_bytes = base64.b64decode(result_b64)
+                        result = cloudpickle.loads(result_bytes)
+                        return result
+                    else:
+                        print(log)
+
+                raise RuntimeError("Job completed but no result was found in the logs.")
+
+            return wrapper
+
+        return decorator
+
     def create_scheduled_job(
         self,
         *,
@@ -11024,6 +11163,7 @@ def _parse_revision_from_pr_url(pr_url: str) -> str:
 inspect_job = api.inspect_job
 cancel_job = api.cancel_job
 run_uv_job = api.run_uv_job
+as_job = api.as_job
 create_scheduled_job = api.create_scheduled_job
 list_scheduled_jobs = api.list_scheduled_jobs
 inspect_scheduled_job = api.inspect_scheduled_job