diff --git a/harfbuzz b/harfbuzz
index b0ffab4..e6741e2 160000
--- a/harfbuzz
+++ b/harfbuzz
@@ -1 +1 @@
-Subproject commit b0ffab42d473eb380ad0fcf42730e0f1868cbc97
+Subproject commit e6741e2205309752839da60ff075b7fa2e7cddd3
diff --git a/setup.py b/setup.py
index f5f9f4a..06652cb 100755
--- a/setup.py
+++ b/setup.py
@@ -124,8 +124,6 @@ def _configure_extensions_with_vendored_libs() -> List[Extension]:
         define_macros.append(("Py_LIMITED_API", limited_api_min_version))
 
     if platform.system() == "Windows" and not emscripten:
-        define_macros.append(("HAVE_DIRECTWRITE", "1"))
-        define_macros.append(("HAVE_UNISCRIBE", "1"))
         define_macros.append(("HB_HAS_DIRECTWRITE", "1"))
         define_macros.append(("HB_HAS_UNISCRIBE", "1"))
         libraries += ["usp10", "gdi32", "user32", "rpcrt4", "dwrite"]
@@ -137,7 +135,6 @@ def _configure_extensions_with_vendored_libs() -> List[Extension]:
         define_macros.append(("HAVE_SYS_MMAN_H", "1"))
 
     if platform.system() == "Darwin" and not emscripten:
-        define_macros.append(("HAVE_CORETEXT", "1"))
         define_macros.append(("HB_HAS_CORETEXT", "1"))
         extra_link_args.extend(["-framework", "ApplicationServices"])