diff --git a/pyproject.toml b/pyproject.toml
index c51deacf..3e2e18b7 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -20,12 +20,23 @@ dependencies = [
 
 [project.optional-dependencies]
 mips = [
+    "splat64[mips-min,assets-n64,compression]",
+]
+
+mips-min = [
     "spimdisasm>=1.42.1,<2.0.0", # This value should be keep in sync with the version listed on disassembler/spimdisasm_disassembler.py
     "rabbitizer>=1.12.0,<2.0.0",
+]
+assets-n64 = [
+    "splat64[mips-min]",
     "pygfxd>=1.0.5",
     "n64img>=0.3.3",
+]
+compression = [
+    "splat64[mips-min]",
     "crunch64>=0.5.1,<1.0.0",
 ]
+
 dev = [
     "splat64[mips]",
     "ruff",
diff --git a/src/splat/segtypes/n64/__init__.py b/src/splat/segtypes/n64/__init__.py
index 70eb16e2..85f4092e 100644
--- a/src/splat/segtypes/n64/__init__.py
+++ b/src/splat/segtypes/n64/__init__.py
@@ -1,21 +1,38 @@
-from . import ci as ci
-from . import ci4 as ci4
-from . import ci8 as ci8
 from . import decompressor as decompressor
-from . import gfx as gfx
 from . import header as header
-from . import i1 as i1
-from . import i4 as i4
-from . import i8 as i8
-from . import ia16 as ia16
-from . import ia4 as ia4
-from . import ia8 as ia8
-from . import img as img
 from . import ipl3 as ipl3
-from . import mio0 as mio0
 from . import palette as palette
-from . import rgba16 as rgba16
-from . import rgba32 as rgba32
 from . import rsp as rsp
 from . import vtx as vtx
-from . import yay0 as yay0
+
+# Segments that require optional dependencies
+
+# assets-n64 (pygfxd)
+try:
+    from . import gfx as gfx
+except ImportError:
+    pass
+
+# assets-n64 (n64img)
+try:
+    from . import ci as ci
+    from . import ci4 as ci4
+    from . import ci8 as ci8
+    from . import i1 as i1
+    from . import i4 as i4
+    from . import i8 as i8
+    from . import ia16 as ia16
+    from . import ia4 as ia4
+    from . import ia8 as ia8
+    from . import img as img
+    from . import rgba16 as rgba16
+    from . import rgba32 as rgba32
+except ImportError:
+    pass
+
+# compression (crunch64)
+try:
+    from . import mio0 as mio0
+    from . import yay0 as yay0
+except ImportError:
+    pass
diff --git a/src/splat/segtypes/segment.py b/src/splat/segtypes/segment.py
index f086a3ea..561c8d7e 100644
--- a/src/splat/segtypes/segment.py
+++ b/src/splat/segtypes/segment.py
@@ -96,11 +96,34 @@ def empty_statistics() -> SegmentStatistics:
     return collections.defaultdict(lambda: SegmentStatisticsInfo(size=0, count=0))
 
 
+# Mapping for segments that are enabled only when the corresponding dependency
+# is available at runtime.
+# The value corresponds to the dependency group listed on the pyproject.toml
+# file installs the required Python dependencies for the given segment.
+_segments_from_optional_dependencies: dict[str, str] = {
+    "yay0": "compression",
+    "mio0": "compression",
+    "gfx": "assets-n64",
+    "ci": "assets-n64",
+    "ci4": "assets-n64",
+    "ci8": "assets-n64",
+    "i1": "assets-n64",
+    "i4": "assets-n64",
+    "i8": "assets-n64",
+    "ia16": "assets-n64",
+    "ia4": "assets-n64",
+    "ia8": "assets-n64",
+    "img": "assets-n64",
+    "rgba16": "assets-n64",
+    "rgba32": "assets-n64",
+}
+
+
 class Segment:
     require_unique_name = True
 
     @staticmethod
-    def get_class_for_type(seg_type) -> Type["Segment"]:
+    def get_class_for_type(seg_type: str) -> Type["Segment"]:
         # so .data loads SegData, for example
         seg_type = seg_type.removeprefix(".")
 
@@ -115,14 +138,21 @@ def get_class_for_type(seg_type) -> Type["Segment"]:
                 segment_class = Segment.get_extension_segment_class(seg_type)
 
         if segment_class is None:
+            dependency_group = _segments_from_optional_dependencies.get(seg_type)
+            if dependency_group is not None:
+                log.error(
+                    f"Could not load segment type '{seg_type}'.\n"
+                    f"This segment is available by installing the optional dependency group `splat64[{dependency_group}]`"
+                )
             log.error(
-                f"could not load segment type '{seg_type}'\n(hint: confirm your extension directory is configured correctly)"
+                f"Could not load segment type '{seg_type}'\n"
+                "(hint: confirm your extension directory is configured correctly)"
             )
 
         return segment_class
 
     @staticmethod
-    def get_base_segment_class(seg_type):
+    def get_base_segment_class(seg_type: str) -> Optional[Type["Segment"]]:
         platform = options.opts.platform
         is_platform_seg = False
 
@@ -144,7 +174,7 @@ def get_base_segment_class(seg_type):
         return getattr(segmodule, f"{seg_prefix}Seg{seg_type.capitalize()}")
 
     @staticmethod
-    def get_extension_segment_class(seg_type):
+    def get_extension_segment_class(seg_type: str) -> Optional[Type["Segment"]]:
         platform = options.opts.platform
 
         ext_path = options.opts.extensions_path
@@ -167,7 +197,8 @@ def get_extension_segment_class(seg_type):
             return None
 
         return getattr(
-            ext_mod, f"{platform.upper()}Seg{seg_type[0].upper()}{seg_type[1:]}"
+            ext_mod,
+            f"{platform.upper()}Seg{seg_type[0].upper()}{seg_type[1:]}",
         )
 
     @staticmethod