diff --git a/src/elements/content-sidebar/ActivitySidebar.js b/src/elements/content-sidebar/ActivitySidebar.js
index b54c62a817..090f5a9d4d 100644
--- a/src/elements/content-sidebar/ActivitySidebar.js
+++ b/src/elements/content-sidebar/ActivitySidebar.js
@@ -440,14 +440,15 @@ class ActivitySidebar extends React.PureComponent<Props, State> {
      * @return void
      */
     deleteComment = ({ id, permissions }: { id: string, permissions: BoxCommentPermission }): void => {
-        const { api, file, hasReplies, onCommentDelete } = this.props;
+        const { api, features, file, hasReplies, onCommentDelete } = this.props;
+        const isThreadedRepliesV2Enabled = isFeatureEnabled(features, 'activityFeed.threadedRepliesV2.enabled');
 
         const successCallback = (comment: Comment) => {
             this.feedSuccessCallback();
             onCommentDelete(comment);
         };
 
-        if (hasReplies) {
+        if (hasReplies || isThreadedRepliesV2Enabled) {
             api.getFeedAPI(false).deleteThreadedComment(file, id, permissions, successCallback, this.feedErrorCallback);
         } else {
             api.getFeedAPI(false).deleteComment(file, id, permissions, successCallback, this.feedErrorCallback);
@@ -669,7 +670,8 @@ class ActivitySidebar extends React.PureComponent<Props, State> {
      * @return {void}
      */
     createComment = (text: string, hasMention: boolean): void => {
-        const { api, currentUser, file, hasReplies, onCommentCreate } = this.props;
+        const { api, currentUser, features, file, hasReplies, onCommentCreate } = this.props;
+        const isThreadedRepliesV2Enabled = isFeatureEnabled(features, 'activityFeed.threadedRepliesV2.enabled');
 
         if (!currentUser) {
             throw getBadUserError();
@@ -680,7 +682,7 @@ class ActivitySidebar extends React.PureComponent<Props, State> {
             this.feedSuccessCallback();
         };
 
-        if (hasReplies) {
+        if (hasReplies || isThreadedRepliesV2Enabled) {
             api.getFeedAPI(false).createThreadedComment(
                 file,
                 currentUser,
diff --git a/src/elements/content-sidebar/__tests__/ActivitySidebar.test.js b/src/elements/content-sidebar/__tests__/ActivitySidebar.test.js
index 0a8411e94c..0692cab1fd 100644
--- a/src/elements/content-sidebar/__tests__/ActivitySidebar.test.js
+++ b/src/elements/content-sidebar/__tests__/ActivitySidebar.test.js
@@ -275,6 +275,31 @@ describe('elements/content-sidebar/ActivitySidebar', () => {
             );
             expect(instance.fetchFeedItems).toBeCalled();
         });
+
+        test('should call the deleteThreadedComment API when threadedRepliesV2 is enabled even if hasReplies is false', () => {
+            const wrapper = getWrapper({
+                features: { activityFeed: { threadedRepliesV2: { enabled: true } } },
+                hasReplies: false,
+            });
+            const instance = wrapper.instance();
+            instance.fetchFeedItems = jest.fn();
+
+            const id = '1';
+            const permissions = {
+                can_edit: false,
+                can_delete: true,
+            };
+            instance.deleteComment({ id, permissions });
+            expect(feedAPI.deleteThreadedComment).toBeCalledWith(
+                file,
+                id,
+                permissions,
+                expect.any(Function),
+                expect.any(Function),
+            );
+            expect(feedAPI.deleteComment).not.toBeCalled();
+            expect(instance.fetchFeedItems).toBeCalled();
+        });
     });
 
     describe('deleteReply()', () => {
@@ -458,6 +483,28 @@ describe('elements/content-sidebar/ActivitySidebar', () => {
             );
             expect(instance.fetchFeedItems).toBeCalled();
         });
+
+        test('should call the createThreadedComment API when threadedRepliesV2 is enabled even if hasReplies is false', () => {
+            const wrapper = getWrapper({
+                features: { activityFeed: { threadedRepliesV2: { enabled: true } } },
+                hasReplies: false,
+            });
+            const instance = wrapper.instance();
+            instance.fetchFeedItems = jest.fn();
+            const message = 'foo';
+            const hasMention = true;
+
+            instance.createComment(message, hasMention);
+            expect(feedAPI.createThreadedComment).toBeCalledWith(
+                file,
+                currentUser,
+                message,
+                expect.any(Function),
+                expect.any(Function),
+            );
+            expect(feedAPI.createComment).not.toBeCalled();
+            expect(instance.fetchFeedItems).toBeCalled();
+        });
     });
 
     describe('createReply()', () => {